INVITRO ACTIVITY OF SPARFLOXACIN COMPARED WITH CIPROFLOXACIN AND OFLOXACIN AGAINST RESPIRATORY-TRACT PATHOGENS

被引：13
|
作者：
MALMBORG, AS
AHLEN, S
机构：
[1] Department of Clinical Microbiology, Huddinge University Hospital
来源：
CHEMOTHERAPY | 1993年 / 39卷 / 01期
关键词：
SPARFLOXACIN; FLUOROQUINOLONE; INVITRO ACTIVITY;
D O I：
10.1159/000238970
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The in vitro activity of sparfloxacin, a new fluoroquinolone, was compared with ciprofloxacin and ofloxacin against 166 consecutive isolates from the upper respiratory tract of outpatients. The strains were fully susceptible to three quinolones. The antibacterial activity of sparfloxacin was comparable or better than that of ofloxacin and ciprofloxacin against all strains. Sparfloxacin was fourfold more active against Staphylococcus aureus and Streptococcus pneumoniae. The favourable MIC values and a prolonged half-life makes sparfloxacin interesting for treating respiratory tract infections in out-patient care.
引用
收藏
页码：32 / 35
页数：4
相关论文
共 28 条
  • [1] INVITRO ACTIVITY OF SPARFLOXACIN AND OTHER ANTIMICROBIAL AGENTS AGAINST GENITAL PATHOGENS
    LEFEVRE, JC
    BAURIAUD, R
    GAUBERT, E
    ESCAFFRE, MC
    LARENG, MB
    CHEMOTHERAPY, 1992, 38 (05) : 303 - 307
  • [2] INVITRO ACTIVITY OF SPARFLOXACIN AGAINST MYCOPLASMAS
    RENAUDIN, H
    BEBEAR, C
    PATHOLOGIE BIOLOGIE, 1992, 40 (05): : 450 - 454
  • [3] In vitro pharmacodynamics of ofloxacin and ciprofloxacin against common ocular pathogens
    Callegan, MC
    Booth, MC
    Gilmore, MS
    CORNEA, 2000, 19 (04) : 539 - 545
  • [4] Bacteriological activity of trovafloxacin, a new quinolone, against respiratory tract pathogens
    J. -C. Pechère
    T. D. Gootz
    European Journal of Clinical Microbiology and Infectious Diseases, 1998, 17 (6) : 405 - 412
  • [5] In Vitro and In Vivo Activity of Moxifloxacin against Community Respiratory Tract Pathogens
    J. M. Blondeau
    D. Felmingham
    Clinical Drug Investigation, 1999, 18 : 57 - 78
  • [6] COMPARED INVITRO ANTIBACTERIAL ACTIVITY OF A NEW FLUOROQUINOLONE, SPARFLOXACIN (AT 4140-RP 64206) AND 4 OTHER FLUOROQUINOLONES AGAINST 332 STRAINS OF ENTERIC PATHOGENS
    LENOC, P
    CROIZE, J
    LENOC, D
    PATHOLOGIE BIOLOGIE, 1993, 41 (04): : 294 - 301
  • [7] Clinical Evaluation of the Tolerability and Efficacy of Trovafloxacin Compared with Sparfloxacin in the Treatment of Lower Respiratory Tract Infections
    Jagdish Chandra Shobha
    T. Ramesh Kumar
    N. Deivanayagam
    Raj B. Singh
    Pradyut Waghray
    P. Aravinda Babu
    Jaydip Bhaduri
    C. Chandra Sekhar
    Clinical Drug Investigation, 2000, 20 : 95 - 100
  • [8] Bactericidal kinetics and postantibiotic effect of sparfloxacin against selected species of respiratory pathogens
    Speciale, A
    Blandino, G
    Nicolosi, VM
    Siracusa, V
    Caccamo, F
    JOURNAL OF CHEMOTHERAPY, 1995, 7 (06) : 530 - 534
  • [9] Comparative in vitro activity of cider and newer fluoroquinolones against respiratory tract pathogens
    Esposito, S
    Noviello, S
    Ianniello, F
    CHEMOTHERAPY, 2000, 46 (05) : 309 - 314
  • [10] In Vitro Activity of Finafloxacin against Panels of Respiratory Pathogens
    Harding, Sarah V.
    Barnes, Kay B.
    Hawser, Stephen
    Bentley, Christine E.
    Vente, Andreas
    ANTIBIOTICS-BASEL, 2023, 12 (07):
123