BEHAVIORAL PHARMACOLOGY OF 5-HT3-RECEPTOR LIGANDS

被引：62
作者：
BARNES, JM [1 ]
BARNES, NM [1 ]
COOPER, SJ [1 ]
机构：
[1] UNIV BIRMINGHAM, SCH PSYCHOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1992年 / 16卷 / 01期
关键词：
5-HT3-RECEPTOR; PSYCHOSIS; ANXIETY; DRUGS OF ABUSE; COGNITION; APPETITE; SOCIAL ENCOUNTERS;
D O I：
10.1016/S0149-7634(05)80057-0
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Extensive studies have ascribed a role for the central 5-HT3 receptor in the modulation of behaviour. Much of the work stems from the actions of potent and selective 5-HT3 receptor antagonists; these agents reduce mesolimbic dopamine initiated hyperactivity, release suppressed behaviour, reduce the reinforcing properties and withdrawal symptoms of drugs of abuse, enhance cognitive performance and modulate appetite. This article reviews the preclinical and clinical evidence implicating the 5-HT3 receptor in these indications and discusses the potential neurochemical mechanisms underlying the behavioural changes.
引用
收藏
页码：107 / 113
页数：7
相关论文
共 123 条
[1]  
ALTMAN HJ, 1987, COGNITIVE NEUROCHEMI, P346
[2]   DIFFERENTIAL EFFECT OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS ON THE SUPPRESSANT ACTION OF 2-METHYLSEROTONIN ON MEDIAL PREFRONTAL CORTICAL-CELLS - A MICROIONTOPHORETIC STUDY [J].
ASHBY, CR ;
EDWARDS, E ;
HARKINS, KL ;
WANG, RY .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 166 (03) :583-584
[3]   CHARACTERIZATION OF 5-HYDROXYTRYPTAMINE3 RECEPTORS IN THE MEDIAL PREFRONTAL CORTEX - A MICROIONTOPHORETIC STUDY [J].
ASHBY, CR ;
EDWARDS, E ;
HARKINS, K ;
WANG, RY .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 173 (2-3) :193-196
[4]  
BARNES J M, 1989, British Journal of Pharmacology, V97, p378P
[5]   IDENTIFICATION AND CHARACTERIZATION OF 5-HYDROXYTRYPTAMINE3 RECOGNITION SITES IN HUMAN-BRAIN TISSUE [J].
BARNES, JM ;
BARNES, NM ;
COSTALL, B ;
IRONSIDE, JW ;
NAYLOR, RJ .
JOURNAL OF NEUROCHEMISTRY, 1989, 53 (06) :1787-1793
[6]   NEUROCHEMICAL CONSEQUENCES FOLLOWING INJECTION OF THE SUBSTANCE-P ANALOG, DIME-C7, INTO THE RAT VENTRAL TEGMENTAL AREA [J].
BARNES, JM ;
BARNES, NM ;
COSTALL, B ;
COX, AJ ;
DOMENEY, AM ;
KELLY, ME ;
NAYLOR, RJ .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 37 (04) :839-841
[7]   5-HT3 RECEPTORS MEDIATE INHIBITION OF ACETYLCHOLINE-RELEASE IN CORTICAL TISSUE [J].
BARNES, JM ;
BARNES, NM ;
COSTALL, B ;
NAYLOR, RJ ;
TYERS, MB .
NATURE, 1989, 338 (6218) :762-763
[8]   THE EFFECTS OF ONDANSETRON, A 5-HT3 RECEPTOR ANTAGONIST, ON COGNITION IN RODENTS AND PRIMATES [J].
BARNES, JM ;
COSTALL, B ;
COUGHLAN, J ;
DOMENEY, AM ;
GERRARD, PA ;
KELLY, ME ;
NAYLOR, RJ ;
ONAIVI, ES ;
TOMKINS, DM ;
TYERS, MB .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (04) :955-962
[9]   CHARACTERIZATION AND AUTORADIOGRAPHIC LOCALIZATION OF 5-HT3 RECEPTOR RECOGNITION SITES IDENTIFIED WITH [3H]-(S)-ZACOPRIDE IN THE FOREBRAIN OF THE RAT [J].
BARNES, JM ;
BARNES, NM ;
CHAMPANERIA, S ;
COSTALL, B ;
NAYLOR, RJ .
NEUROPHARMACOLOGY, 1990, 29 (11) :1037-&
[10]   THE DIFFERENTIAL ACTIVITIES OF R(+)-ZACOPRIDE AND S(-)-ZACOPRIDE AS 5-HT3 RECEPTOR ANTAGONISTS [J].
BARNES, JM ;
BARNES, NM ;
COSTALL, B ;
DOMENEY, AM ;
JOHNSON, DN ;
KELLY, ME ;
MUNSON, HR ;
NAYLOR, RJ ;
YOUNG, R .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 37 (04) :717-727
12345678910