Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine

被引:23
作者
Stehouwer, Jeffrey S. [1 ,2 ]
Goodman, Mark M. [1 ,2 ]
机构
[1] Emory Univ, Ctr Syst Imaging, Sch Med, Dept Radiol, Atlanta, GA 30329 USA
[2] Wesley Woods Hlth Ctr, Dept Radiol, 2nd Floor,WWHC 209,1841 Clifton Rd NE, Atlanta, GA 30329 USA
关键词
Fluorine-18; PET; Tropanes; Dopamine transporter; Serotonin transporter; Norepinephrine transporter;
D O I
10.1016/j.cpet.2009.05.006
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This article focuses on the development of fluorine-18 radiolabeled PET tracers for imaging the dopamine transporter, serotonin transporter, and norepinephrine transporter. All successful dopamine transporter PET tracers reported to date are members of the 3 beta-phenyltropane class and are synthesized from cocaine. Currently available carbon-11 serotonin transporter PET tracers come from both the diphenyl-sulfide and 3 beta-phenylnortropane class, but so far only the nortropanes have found success with fluorine-18 derivatives. Norepinephrine transporter imaging has so far used carbon-11 and fluorine-18 derivatives of reboxetine but because of defluorination of the fluorine-18 derivatives further research is still necessary.
引用
收藏
页码:101 / +
页数:29
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