SYNTHESIS AND STRUCTURE ACTIVITY STUDIES ON A SERIES OF TRICYCLIC TERTIARY-AMINES WITH HIGH-AFFINITY AND SELECTIVITY FOR THE 5-HT1A SUBTYPE OF THE SEROTONIN RECEPTOR

被引:0
|
作者
MEYER, MD [1 ]
SIPPY, KB [1 ]
HANCOCK, AA [1 ]
STANISIC, D [1 ]
LEE, JY [1 ]
BUCKNER, S [1 ]
DEBERNARDIS, JF [1 ]
机构
[1] ABBOTT LABS,DIV PHARMACEUT PROD,ABBOTT PK,IL 60064
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:100 / MEDI
相关论文
共 50 条
  • [1] ARYLPIPERAZINE DERIVATIVES AS HIGH-AFFINITY 5-HT1A SEROTONIN LIGANDS
    GLENNON, RA
    NAIMAN, NA
    LYON, RA
    TITELER, M
    JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (10) : 1968 - 1971
  • [2] [H-3] 5-METHYL-URAPIDIL BINDS WITH HIGH-AFFINITY TO SEROTONIN RECEPTORS OF THE 5-HT1A SUBTYPE
    SCHUTTLER, K
    GROSS, G
    XIN, X
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (03) : 1108 - 1108
  • [3] Two-dimensional QSAR studies on arylpiperazines as high-affinity 5-HT1A receptor ligands
    Weber, Karen C.
    Honorio, Kathia M.
    Andricopulo, Adriano D.
    Da Silva, Alberico B. F.
    MEDICINAL CHEMISTRY, 2008, 4 (04) : 328 - 335
  • [4] TRICYCLIC ANTIDEPRESSANT DRUGS EXHIBIT HIGH-AFFINITY FOR SEROTONIN (5HT)1C RECEPTORS
    WONG, DT
    THRELKELD, PG
    FASEB JOURNAL, 1993, 7 (03): : A264 - A264
  • [5] Synthesis and structure-activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds
    Cappelli, Andrea
    Manini, Monica
    Valenti, Salvatore
    Castriconi, Federica
    Giuliani, Germano
    Anzini, Maurizio
    Brogi, Simone
    Butini, Stefania
    Gemma, Sandra
    Campiani, Giuseppe
    Giorgi, Gianluca
    Mennuni, Laura
    Lanza, Marco
    Giordani, Antonio
    Caselli, Gianfranco
    Letari, Ornella
    Makovec, Francesco
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 63 : 85 - 94
  • [6] Synthesis of New Serotonin 5-HT7 Receptor Ligands. Determinants of 5-HT7/5-HT1A Receptor Selectivity
    Medina, Rocio A.
    Sallander, Jessica
    Benhamu, Bellinda
    Porras, Esther
    Campillo, Mercedes
    Pardo, Leonardo
    Lopez-Rodriguez, Maria L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (08) : 2384 - 2392
  • [7] 5-HT1A RECEPTOR-MEDIATED ACTIVATION OF HIGH-AFFINITY GTPASE IN RAT HIPPOCAMPAL MEMBRANES
    ODAGAKI, Y
    FUXE, K
    EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1995, 288 (03): : 385 - 388
  • [8] BMY-7378, A BUSPIRONE ANALOG WITH HIGH-AFFINITY, SELECTIVITY AND LOW INTRINSIC ACTIVITY AT THE 5-HT1A RECEPTOR IN RAT AND GUINEA-PIG HIPPOCAMPAL MEMBRANES
    YOCCA, FD
    HYSLOP, DK
    SMITH, DW
    MAAYANI, S
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 137 (2-3) : 293 - 294
  • [9] POTENTIAL ANTIDEPRESSANT PROPERTIES OF SR 57746A, A NOVEL COMPOUND WITH SELECTIVITY AND HIGH-AFFINITY FOR 5-HT1A RECEPTORS
    CERVO, L
    BENDOTTI, C
    TARIZZO, G
    CAGNOTTO, A
    SKORUPSKA, M
    MENNINI, T
    SAMANIN, R
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 253 (1-2) : 139 - 147
  • [10] Quantitative Structure-Activity Relationship for High Affinity 5-HT1A Receptor Ligands Based on Norm Indexes
    Jia, Qingzhu
    Cui, Xue
    Li, Lei
    Wang, Qiang
    Liu, Ying
    Xia, Shuqian
    Ma, Peisheng
    JOURNAL OF PHYSICAL CHEMISTRY B, 2015, 119 (51): : 15561 - 15567