A SIMPLE AND HIGHLY STEREOSELECTIVE ROUTE TO E-ALPHA,BETA-UNSATURATED ALDEHYDES

被引：60
作者：
BELLASSOUED, M
MAJIDI, A
机构：
[1] Université Pierre et Marie Curie, Laboratoire de Synthèse Organométallique, CNRS UA 408, 75252 Paris Cedex 05, 4, Place Jussieu
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 09期
关键词：
D O I：
10.1021/jo00061a027
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Zinc bromide mediated reaction of alpha,alpha-bis(trimethylsilyl)-tert-butylacetaldimine (3) with a wide range of aldehydes takes place under mild conditions and affords the corresponding alpha,beta-unsaturated aldehydes in good yields and with very high E stereoselectivity (>98%). This procedure is successfully applied to the preparation of intermediates for retinoid and natural product synthesis.
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页码：2517 / 2522
页数：6
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