IMPACT OF 4-WEEK METOPROLOL THERAPY ON CLINICAL MANIFESTATIONS AND CARDIAC HEMODYNAMICS IN PATIENTS WITH CORONARY HEART-DISEASE

Metoprolol was examined for its effects on clinical manifestations of the disease, peripheral hemodynamic and myocardial contractile parameters in 46 patients with coronary heart disease. The examination was performed during an acute drug test and continuous treatment for 4 weeks. The efficiency of the therapy was monitored by conventional clinical tools, bicycle ergometric test, studies of intracardiac hemodynamic parameters from echocardiographic evidence. With metoprolol, its antianginal effect was attained in 67.5% of the patients, there were significant antihypertensive and negative chronotropic effects and moderate cardiodepressive action.