SERUM LEVELS OF INTERLEUKIN-6 ARE NOT ELEVATED IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：75

作者：

VANDUIJN, CM ^{[1
]}

HOFMAN, A ^{[1
]}

NAGELKERKEN, L ^{[1
]}

机构：

[1] TNO, INST EXPTL GERONTOL, DEPT IMMUNOL, RIJSWIJK, NETHERLANDS

来源：

NEUROSCIENCE LETTERS | 1990年 / 108卷 / 03期

关键词：

Acute-phase response; Alzheimer's disease; Interleukin-6;

D O I：

10.1016/0304-3940(90)90666-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serum levels of interleukin-6 (IL-6) were determined in 97 patients with clinically diagnosed Alzheimer's disease and 79 age- and sex-matched control subjects. Median serum levels of IL-6 did not differ significantly between Alzheimer patients (8.6 U/ml) and controls (8.2 U/ml). Median levels of serum IL-6 were similar for sporadic and familial patients. The concentration of IL-6 was not associated with the severity of the dementia or the duration of the disease since first symptoms. According to these observations there is no evidence for a significant elevation in serum IL-6 in Alzheimer's disease. © 1990.

引用

页码：350 / 354

页数：5

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