INHIBITION OF NITRIC-OXIDE SYNTHASE BY ANTINEOPLASTIC ANTHRACYCLINES

被引：21

作者：

LUO, DS ^{[1
]}

VINCENT, SR ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,DIV NEUROL SCI,VANCOUVER V6T 1Z3,BC,CANADA

来源：

BIOCHEMICAL PHARMACOLOGY | 1994年 / 47卷 / 11期

基金：

英国医学研究理事会;

关键词：

DOXORUBICIN; ACLARUBICIN; NITRIC OXIDE SYNTHASE; CHEMOTHERAPEUTICS; ANTHRACYCLINE ANTIBIOTICS;

D O I：

10.1016/0006-2952(94)90088-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nitric oxide synthase, the enzyme responsible for the synthesis of nitric oxide and citrulline from arginine, was potently inhibited by the anthracycline antibiotics doxorubicin (K-i = 24 mu M) and aclarubicin (K-i = 50 mu M). These drugs were non-competitive inhibitors with respect to arginine. This action on nitric oxide synthase may explain some of the cardiovascular and cytotoxic actions of these chemotherapeutic drugs.

引用

页码：2111 / 2112

页数：2

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