INHIBITION OF NITRIC-OXIDE SYNTHASE BY ANTINEOPLASTIC ANTHRACYCLINES

被引:20
|
作者
LUO, DS [1 ]
VINCENT, SR [1 ]
机构
[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,DIV NEUROL SCI,VANCOUVER V6T 1Z3,BC,CANADA
基金
英国医学研究理事会;
关键词
DOXORUBICIN; ACLARUBICIN; NITRIC OXIDE SYNTHASE; CHEMOTHERAPEUTICS; ANTHRACYCLINE ANTIBIOTICS;
D O I
10.1016/0006-2952(94)90088-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nitric oxide synthase, the enzyme responsible for the synthesis of nitric oxide and citrulline from arginine, was potently inhibited by the anthracycline antibiotics doxorubicin (K-i = 24 mu M) and aclarubicin (K-i = 50 mu M). These drugs were non-competitive inhibitors with respect to arginine. This action on nitric oxide synthase may explain some of the cardiovascular and cytotoxic actions of these chemotherapeutic drugs.
引用
收藏
页码:2111 / 2112
页数:2
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