LYOAVAILABILITY OF NORDAZEPAM SOLID DISPERSIONS IN RELATION WITH PHASE-DIAGRAMS

被引：1
|
作者：
ELMOUSSAOUI, A
CHAUVET, A
MASSE, J
GAUDY, D
PUECH, A
机构：
[1] FAC PHARM MONTPELLIER,CHIM GEN & MINERALE LAB,F-34060 MONTPELLIER 1,FRANCE
[2] FAC PHARM MONTPELLIER,PHARM GALEN PHARMACOTECHN & BIOPHARM LAB,F-34060 MONTPELLIER 1,FRANCE
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 106卷 / 02期
关键词：
NORDAZEPAM; SOLID DISPERSION; LYOAVAILABILITY;
D O I：
10.1016/0378-5173(94)90308-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We have prepared solid dispersions (melt, coprecipitate) of nordazepam III (NDZ) with carriers polyoxyethylene glycol (PEG 6000), succinic acid, and with another drug, nicotinic acid, corresponding to the eutectic composition. From a study of the dissolution kinetics, we found that the highest value is obtained for the PEG 6000 melt. We have shown that there is a good correlation between PEG solid dispersion dissolution kinetics and mixing enthalpies.
引用
收藏
页码：109 / 114
页数：6
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