SYNTHESIS OF DIACYLGLYCEROL ANALOGS AS POTENTIAL 2ND-MESSENGER ANTAGONISTS AND INHIBITORS OF PROTEIN-KINASE-C

被引：9

作者：

BRIGGS, JC

HAINES, AH

TAYLOR, RJK

DAWSON, AP

GIBSON, I

HOOK, J

LLOYD, A

MEINERS, S

机构：

[1] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

[2] UNIV E ANGLIA,SCH BIOL SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

来源：

CARBOHYDRATE RESEARCH | 1992年 / 234卷

关键词：

D O I：

10.1016/0008-6215(92)85036-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of analogues of diacylglycerol has been prepared and tested as inhibitors of protein kinase C (PKC). The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-0-acetyl-1-0-oleoylglycerol. Compound 24 was the most effective inhibitor of the growth of MR4 and HT29 cells in culture, and 26 was more effective than 24 against HL60 cells.

引用

页码：23 / 35

页数：13

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