RECOMBINANT-HUMAN-ERYTHROPOIETIN REDUCES FREE ERYTHROCYTE PROTOPORPHYRIN LEVELS IN PATIENTS ON CHRONIC DIALYSIS

被引：16
|
作者：
PIAZZA, V
VILLA, G
GALLI, F
SEGAGNI, S
BOVIO, G
POGGIO, F
PICARDI, L
SALVADEO, A
机构：
[1] Div. di Nefrologia ed Emodiali, Fondazione Clinica del Lavoro, I-27100 Pavia
来源：
NEPHRON | 1992年 / 61卷 / 01期
关键词：
ERYTHROPOIETIN; HEME; HEMODIALYSIS; PORPHYRINS;
D O I：
10.1159/000186834
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We studied the significance of free erythrocyte protoporphyrin (FEP) in relation to iron status, aluminum levels and anemia in uremic patients on chronic dialysis. All but 1 patient showed high FEP values closely related to the degree of anemia. Increased FEP levels are due to a defective heme synthesis, not related to iron deficiency or aluminum overload. Treatment of anemia with recombinant human erythropoietin reduced FEP values. We therefore hypothesize that recombinant human erythropoietin ameliorates an enzymatic defect in heme synthesis.
引用
收藏
页码：54 / 57
页数：4
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