A NEW APPROACH TO THE SYNTHESIS OF LAVENDAMYCIN ANALOGS

被引：27

作者：

ROCCA, P ^{[1
]}

MARSAIS, F ^{[1
]}

GODARD, A ^{[1
]}

QUEGUINER, G ^{[1
]}

机构：

[1] INSA,CHIM ORGAN FINE & HETEROCYCL LAB,CNRS,BP 08,F-76131 MONT ST AIGNAN,FRANCE

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 18期

关键词：

ALKALOID; BETA-CARBOLINE; CROSS-COUPLING; HALOPYRIDINES; METALATION;

D O I：

10.1016/S0040-4039(00)60486-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-steps approach to the lavendamycin skeleton from benzene, pyridine and quinoline blocks is described. It is based on a new synthetic methodology for the preparation of alpha-substituted beta-carbolines which involves such reactions as Directed Ortho Metalation and Heteroring Cross-Coupling.

引用

页码：2937 / 2940

页数：4

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