FURTHER ANALYSIS OF THE COGNITIVE EFFECTS OF TETRAHYDROAMINOACRIDINE (THA) IN ALZHEIMERS-DISEASE - ASSESSMENT OF ATTENTIONAL AND MNEMONIC FUNCTION USING CANTAB

被引：202

作者：

SAHAKIAN, BJ ^{[1
]}

OWEN, AM ^{[1
]}

MORANT, NJ ^{[1
]}

EAGGER, SA ^{[1
]}

BODDINGTON, S ^{[1
]}

CRAYTON, L ^{[1
]}

CROCKFORD, HA ^{[1
]}

CROOKS, M ^{[1
]}

HILL, K ^{[1
]}

LEVY, R ^{[1
]}

机构：

[1] INST PSYCHIAT, OLD AGE PSYCHIAT SECT, LONDON SE5 8AF, ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1993年 / 110卷 / 04期

基金：

英国惠康基金;

关键词：

TETRAHYDROAMINOACRIDINE (THA); DEMENTIA OF THE ALZHEIMER TYPE (DAT); ATTENTION; MEMORY; CANTAB;

D O I：

10.1007/BF02244644

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Results of a placebo controlled cross-over trial (N = 89) of the anticholinesterase drug THA as a treatment for dementia of the Alzheimer's type (DAT) are reported, with reference to previous trials of the drug and the cholinergic hypothesis of aging and dementia. Using computerised tests sensitive to specific aspects of memory and attention, evidence is found for improvements in attentional function rather than memory, in patients with mild to moderate DAT. Although these improvements were significant, they were small and restricted to certain tests of attentional function. Nevertheless, they add to the growing body of evidence that the cholinergic system is involved in the control of attentional processes. The results will be relevant to future investigations into the therapeutic effects of enhancement of the cholinergic system in DAT sufferers.

引用

页码：395 / 401

页数：7

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