INTEGRATING CHROMOSOME STRUCTURE WITH FUNCTION

被引：55
作者：
RATTNER, JB
机构：
[1] Department of Anatomy and Medical Biochemistry, University of Calgary, Calgary, T2N 1N4, Alberta
来源：
CHROMOSOMA | 1992年 / 101卷 / 5-6期
关键词：
D O I：
10.1007/BF00346003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Historically, the metaphase chromosome and its architecture has been viewed as the ultimate representation of a non-functional inactive chromatin state. Recent studies of centromere (kinetochore) function in concert with studies of the placement and function of several classes of chromosomal proteins now call for a reevaluation of this view. In this article a model of chromosome structure with functional correlates is presented. Evidence for the existence of a functional chromosomal region, the "Surface Domain" is discussed.
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收藏
页码：259 / 264
页数：6
相关论文
共 34 条
  • [1] GENES OCCUPY A FIXED AND SYMMETRICAL POSITION ON SISTER CHROMATIDS
    BAUMGARTNER, M
    DUTRILLAUX, B
    LEMIEUX, N
    LILIENBAUM, A
    PAULIN, D
    VIEGASPEQUIGNOT, E
    [J]. CELL, 1991, 64 (04) : 761 - 766
  • [2] DISRUPTION OF CENTROMERE ASSEMBLY DURING INTERPHASE INHIBITS KINETOCHORE MORPHOGENESIS AND FUNCTION IN MITOSIS
    BERNAT, RL
    DELANNOY, MR
    ROTHFIELD, NF
    EARNSHAW, WC
    [J]. CELL, 1991, 66 (06) : 1229 - 1238
  • [3] Centromeres and kinetochores: integrated domains on eukaryotic chromosomes
    Brinkley, B. R.
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1990, 2 (03) : 446 - 452
  • [4] CHANGES IN DISTRIBUTION OF NUCLEAR MATRIX ANTIGENS DURING THE MITOTIC CELL-CYCLE
    CHALY, N
    BLADON, T
    SETTERFIELD, G
    LITTLE, JE
    KAPLAN, JG
    BROWN, DL
    [J]. JOURNAL OF CELL BIOLOGY, 1984, 99 (02) : 661 - 671
  • [5] CENP-B - A MAJOR HUMAN CENTROMERE PROTEIN LOCATED BENEATH THE KINETOCHORE
    COOKE, CA
    BERNAT, RL
    EARNSHAW, WC
    [J]. JOURNAL OF CELL BIOLOGY, 1990, 110 (05) : 1475 - 1488
  • [6] THE INNER CENTROMERE PROTEIN (INCENP) ANTIGENS - MOVEMENT FROM INNER CENTROMERE TO MIDBODY DURING MITOSIS
    COOKE, CA
    HECK, MMS
    EARNSHAW, WC
    [J]. JOURNAL OF CELL BIOLOGY, 1987, 105 (05) : 2053 - 2067
  • [7] THE METAPHASE SCAFFOLD IS HELICALLY FOLDED - SISTER CHROMATIDS HAVE PREDOMINANTLY OPPOSITE HELICAL HANDEDNESS
    DELATOUR, EB
    LAEMMLI, UK
    [J]. CELL, 1988, 55 (06) : 937 - 944
  • [8] DILWORTH SM, 1991, J CELL SCI, V98, P309
  • [9] TOPOISOMERASE-II IS A STRUCTURAL COMPONENT OF MITOTIC CHROMOSOME SCAFFOLDS
    EARNSHAW, WC
    HALLIGAN, B
    COOKE, CA
    HECK, MMS
    LIU, LF
    [J]. JOURNAL OF CELL BIOLOGY, 1985, 100 (05) : 1706 - 1715
  • [10] EARNSHAW WC, 1991, J CELL SCI, V98, P443
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