ETS-1 AND ETS-2 PROTOONCOGENE EXPRESSION IN THECA CELLS OF THE ADULT-MOUSE OVARY

被引：12

作者：

ROWE, A ^{[1
]}

PROPST, F ^{[1
]}

机构：

[1] ST MARYS HOSP,SCH MED,LUDWIG INST CANC RES,NORFOLK PL,LONDON W2 1PG,ENGLAND

来源：

EXPERIMENTAL CELL RESEARCH | 1992年 / 202卷 / 01期

关键词：

D O I：

10.1016/0014-4827(92)90420-D

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated the mRNA expression of the Ets-1 and Ets-2 genes in murine gonads and found expression in adult ovaries. In situ hybridization experiments show that the Ets genes are predominantly expressed in theca cells and cells of ovarian interstitium. By gel retardation experiments we detected DNA binding proteins in ovaries that specifically bind to the ETS motif, suggesting the expression of Ets or Ets-related proteins. Our results raise the possibility of Ets-2 involvement in ovarian pathology seen in patients with Down's syndrome. © 1992.

引用

页码：199 / 202

页数：4

共 27 条

[1]

[Anonymous], 1986, MANIPULATING MOUSE E

[2] TEMPORAL AND TISSUE-SPECIFIC EXPRESSION OF MOUSE ETS GENES [J].

BHAT, NK ;

FISHER, RJ ;

FUJIWARA, S ;

ASCIONE, R ;

PAPAS, TS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) :3161-3165

[3] ANDROGEN BIOSYNTHESIS IN DEVELOPING OVARIAN FOLLICLES - EVIDENCE THAT LUTEINIZING-HORMONE REGULATES THECAL 17 ALPHA-HYDROXYLASE AND C-17-20-LYASE ACTIVITIES [J].

BOGOVICH, K ;

RICHARDS, JS .

ENDOCRINOLOGY, 1982, 111 (04) :1201-1208

[4] MOLECULAR-CLONING OF THE ETS-PROTO-ONCOGENE OF THE SEA-URCHIN AND ANALYSIS OF ITS DEVELOPMENTAL EXPRESSION [J].

CHEN, ZQ ;

KAN, NC ;

PRIBYL, L ;

LAUTENBERGER, JA ;

MOUDRIANAKIS, E ;

PAPAS, TS .

DEVELOPMENTAL BIOLOGY, 1988, 125 (02) :432-440

[5] REQUIREMENT OF ETS-2 EXPRESSION FOR XENOPUS OOCYTE MATURATION [J].

CHEN, ZQ ;

BURDETT, LA ;

SETH, AK ;

LAUTENBERGER, JA ;

PAPAS, TS .

SCIENCE, 1990, 250 (4986) :1416-1418

[6]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[7]

FISHER RJ, 1991, ONCOGENE, V6, P2249

[8] SEQUENCE-SPECIFIC DNA-BINDING OF THE PROTO-ONCOPROTEIN ETS-1 DEFINES A TRANSCRIPTIONAL ACTIVATOR SEQUENCE WITHIN THE LONG TERMINAL REPEAT OF THE MOLONEY MURINE SARCOMA-VIRUS [J].

GUNTHER, CV ;

NYE, JA ;

BRYNER, RS ;

GRAVES, BJ .

GENES & DEVELOPMENT, 1990, 4 (04) :667-679

[9] THE COLLAGENASE GENE PROMOTER CONTAINS A TPA AND ONCOGENE-RESPONSIVE UNIT ENCOMPASSING THE PEA3 AND AP-1 BINDING-SITES [J].

GUTMAN, A ;

WASYLYK, B .

EMBO JOURNAL, 1990, 9 (07) :2241-2246

[10] FOLLICULAR DEVELOPMENT IN OVARIES OF CHILDREN WITH DOWNS-SYNDROME [J].

HOJAGER, B ;

PETERS, H ;

BYSKOV, AG ;

FABER, M .

ACTA PAEDIATRICA SCANDINAVICA, 1978, 67 (05) :637-643

← 1 2 3 →