ETS-1 AND ETS-2 PROTOONCOGENE EXPRESSION IN THECA CELLS OF THE ADULT-MOUSE OVARY

被引：12
作者：
ROWE, A [1 ]
PROPST, F [1 ]
机构：
[1] ST MARYS HOSP,SCH MED,LUDWIG INST CANC RES,NORFOLK PL,LONDON W2 1PG,ENGLAND
来源：
EXPERIMENTAL CELL RESEARCH | 1992年 / 202卷 / 01期
关键词：
D O I：
10.1016/0014-4827(92)90420-D
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have investigated the mRNA expression of the Ets-1 and Ets-2 genes in murine gonads and found expression in adult ovaries. In situ hybridization experiments show that the Ets genes are predominantly expressed in theca cells and cells of ovarian interstitium. By gel retardation experiments we detected DNA binding proteins in ovaries that specifically bind to the ETS motif, suggesting the expression of Ets or Ets-related proteins. Our results raise the possibility of Ets-2 involvement in ovarian pathology seen in patients with Down's syndrome. © 1992.
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页码：199 / 202
页数：4
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