PROLACTIN DIRECTLY STIMULATES CITRATE PRODUCTION AND MITOCHONDRIAL ASPARTATE-AMINOTRANSFERASE OF PROSTATE EPITHELIAL-CELLS

被引：24
作者：
FRANKLIN, RB [1 ]
COSTELLO, LC [1 ]
机构：
[1] UNIV MARYLAND,SCH DENT,DEPT PHYSIOL,666 W BALTIMORE ST,BALTIMORE,MD 21201
来源：
PROSTATE | 1990年 / 17卷 / 01期
关键词：
lateral prostate; phorbol ester; pig prostate; protein kinase C; testosterone;
D O I：
10.1002/pros.2990170103
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Prolactin, in vitro, significantly increased citrate production, mAAT (mitochondrial aspartate aminotransferase) and pmAAT (precursor form of mAAT) activity of prostate epithelial cells derived from rat lateral prostate (LP) and pig prostate cultures. In contrast, prolactin had no effect on the cytosolic isozyme, cAAT. This prolactin effect appeared to be independent of testosterone. The phorbol ester TPA (12‐O‐tetradecanoyl‐phorbol‐13‐acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：13 / 18
页数：6
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