VASECTOMY INCREASES SEVERITY OF DIET-INDUCED ATHEROSCLEROSIS IN MACACA-FASCICULARIS

被引：147

作者：

ALEXANDER, NJ ^{[1
]}

CLARKSON, TB ^{[1
]}

机构：

[1] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, ARTERIOSCLEROSIS RES CTR, WINSTON SALEM, NC 27103 USA

来源：

SCIENCE | 1978年 / 201卷 / 4355期

关键词：

D O I：

10.1126/science.96532

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diet-induced atherosclerosis developed more extensively in vasectomized cynomolgus monkeys (M. fascicularis) than in sham-vasectomized control monkeys fed the same diet. the effect was most pronounced in the abdominal aortas, carotid arteries, distal segments of the coronary arteries and intracranial cerebral arteries. Antibodies to sperm developed in all vasectomized monkeys and complement and immunoglobulins were associated with atherosclerotic plaques in some of the vasectomized animals. The immunological response to sperm antigens that often accompanies vasectomy may exacerbate atherosclerosis.

引用

页码：538 / 541

页数：4