Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms

被引：25
作者：
Dao, Ro-Lan [1 ,2 ,3 ]
Su, Shih-Chi [1 ,2 ,3 ]
Chung, Wen-Hung [1 ,2 ,3 ]
机构：
[1] Chang Gung Mem Hosp, Drug Hypersensit Clin & Res Ctr, Dept Dermatol, Taipei, Taiwan
[2] Chang Gung Mem Hosp, Drug Hypersensit Clin & Res Ctr, Dept Dermatol, Keelung, Taiwan
[3] Chang Gung Univ, Coll Med, Taoyuan 33302, Taiwan
来源：
ASIA PACIFIC ALLERGY | 2015年 / 5卷 / 02期
关键词：
Stevens-Johnson syndrome; Toxic epidermal necrolysis; Drug reaction with eosinophilia and systemic symptoms;
D O I：
10.5415/apallergy.2015.5.2.59
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to lifelong sequelae. Many pharmacogenomic associations in immune and nonimmune related genes with the development of SCAR have been discovered recently and the pharmacogenetic tests have been applied to prevent specific drug-induced SCAR. In this review, we discuss the recent advances of pharmacogenomics in SCAR.
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收藏
页码：59 / 67
页数：9
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