AGE-RELATED ALTERATIONS IN SENSITIVITY OF MUSCARINIC AND SEROTONERGIC RESPONSES OF GUINEA-PIG TRACHEA TO REMOVAL OF EXTRACELLULAR CA2+

被引：0

作者：

COX, DA ^{[1
]}

COHEN, ML ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY RES LABS,DEPT CARDIOVASC PHARMACOL 0821,INDIANAPOLIS,IN 46285

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 258卷 / 03期

关键词：

CA2+; 5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); CARBAMYLCHOLINE; TRACHEA;

D O I：

10.1016/0014-2999(94)90489-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Contractile responses to carbamylcholine and 5-hydroxytryptamine (5-HT) in the presence and absence of extracellular Ca2+ were compared in tracheal rings from 3-4-week-old and 7-8-week-old guinea pigs. Contraction to carbamylcholine and 5-HT did not differ in potency or maximal response between age groups in the presence of extracellular Ca2+. However, removal of extracellular Ca2+ inhibited maximal contraction mediated by both agonists to a greater extent in younger versus older guinea pigs. These data suggest that carbamylcholine- and 5-HT-induced contraction of guinea pig trachea from younger animals is more dependent on extracellular Ca2+ as compared to mature animals, and may be related to an age-dependent maturation of sarcoplasmic reticulum function in smooth muscle.

引用

页码：265 / 268

页数：4

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