To Study the Prevalence of Impaired Glucose Tolerance in Patients with Hepatitis C Virus Related Chronic Liver Disease

Background: Hepatitis C infection is a major cause of Chronic Liver Disease and the prevalence of Diabetes Mellitus is also high. Diabetes has been hypothesised as one of Extrahepatic manifestations of Hepatitis C. Aims and Objectives: The objective of our study was to study the prevalence of impaired glucose tolerance in patients with HCV related liver disease. Study Design: The study was a prospective study conducted over a period of one and half year in Dayanand Medical College and Hospital, Ludhiana, Punjab, India. Materials and Methods: The study was conducted taking total of 100 Hepatitis C virus positive patients above 40 years of age who had fasting blood glucose levels >110mg/dl on two occasions, 24 hours apart. These patients underwent an oral glucose tolerance test. Blood sugar levels were tested at 0 and 2 hours. Based on the findings, patients were classified to have impaired glucose tolerance if levels were between 140-200mg/ dl and frank diabetes if the levels were >200mg/d. These findings were further assessed according to age, gender, Body Mass Index (BMI) Child Turcott Pugh score and Ultrasonography findings. Statistical Analysis: In our study all the statistical analysis was done using simple z-test and student t-test. The p-values were calculated and the results assessed accordingly. Results and Conclusion: Out of 100 patients, 78 were males and rest females. The mean age of the study group was 55.89+11.22 years. Mean BMI of males was higher than in females (21.98kg/m(2) v/s 20.13kg/m(2)). Maximum patients belonged to Child Turcott Pugh class C. Out of 100 patients, 80 had cirrhosis on ultrasound. On doing Glucose Tolerance Test, 40 patients were found to have impaired glucose tolerance and one patient to be diabetic. The prevalence increased significantly as age increased and had significant relation with gender. On assessing according to BMI, there was not much significant relation but prevalence was significantly related to severity of disease.