DOPAMINERGIC ANTAGONISM AND CATALEPSY IN THE DEVELOPING RAT

被引：23

作者：

BAEZ, LA ^{[1
]}

BURT, DK ^{[1
]}

GRANNEMAN, J ^{[1
]}

SHANKLIN, C ^{[1
]}

机构：

[1] SO ILLINOIS UNIV,SCH MED,CARBONDALE,IL 62901

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 54卷 / 1-2期

关键词：

Catalepsy; Cholinergic; Development; Dopamine; Haloperidol; Neuroleptic; Spiroperidol;

D O I：

10.1016/0014-2999(79)90402-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cataleptic effect of the dopaminergic blockers spiroperidol and haloperidol was investigated in developing rats. Both neuroleptics were found to produce less catalepsy in 15 day old rats than in either 10 or 20 day old animals. It is proposed that the decrement in catalepsy occuring between 10 and 15 days of age is related to increased dopaminergic activity in the neostriatum. The reversal of this phenomenon by 20 days may be a consequence of maturation of cholinergic local circuit neurons. © 1979.

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页码：15 / 20

页数：6

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