DIPHTHERIA TOXIN SUBUNIT ACTIVE IN VITRO

被引：75

作者：

COLLIER, RJ

COLE, HA

机构：

[1] Department of Bacteriology, University of California, Los Angeles, CA

来源：

SCIENCE | 1969年 / 164卷 / 3884期

关键词：

D O I：

10.1126/science.164.3884.1179

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exposure of diphtheria toxin to dithiothreitol (and similar thiols) resulted in a subunit which was active in catalyzing the adenosine diphosphate-ribosylation of mammalian aminoacyl-transferase II in the presence of nicotinamide adenine dinucleotide. At the same time there was a marked increase in total ADP-ribosylation activity. A molecule which was apparently identical to the derived subunit in size and activity was detected in partially purified preparations of toxin.

引用

页码：1179 / &

共 18 条

[1]

BIZZINI B, 1963, B SOC CHIM BIOL, V45, P925

[2]

COLLIER RG, IN PRESS

[3] EFFECT OF DIPHTHERIA TOXIN ON PROTEIN SYNTHESIS - INACTIVATION OF 1 OF TRANSFER FACTORS [J].