DNA DAMAGE AND REPAIR IN BRAIN - RELATIONSHIP TO AGING

被引：0
|
作者：
RAO, KS
LOEB, LA
机构：
[1] UNIV WASHINGTON, SCH MED, DEPT PATHOL SM-30, JOSEPH GOTTSTEIN MEM CANC RES LAB, SEATTLE, WA 98195 USA
[2] UNIV HYDERABAD, SCH LIFE SCI, NEUROBIOCHEM LAB, HYDERABAD 500134, ANDHRA PRADESH, INDIA
来源：
MUTATION RESEARCH | 1992年 / 275卷 / 3-6期
关键词：
DNA DAMAGE; DNA REPAIR; BRAIN; AGING; NEURONS;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The usefulness of conducting DNA damage and repair studies in a postmitotic tissue like brain is emphasized. We review studies that use brain as a tissue to test the validity of the DNA damage and repair hypothesis of aging. As far as the accumulation of age dependent DNA damage is concerned, the data appear to overwhelmingly support the hypothesis. However, attempts to demonstrate a decline in DNA repair capacity as a function of age are conflicting and equally divided. Possible reasons for this discrepancy are discussed. It is suggested that assessment of the repair capacity of neurons with respect to a specific type of damage in a specific gene might yield more definitive answers regarding the role of DNA repair potential in the aging process and as a longevity assurance system.
引用
收藏
页码：317 / 329
页数：13
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