OPTICAL RESOLUTION OF CHLORPHENIRAMINE BY CYCLODEXTRIN ADDED CAPILLARY ZONE ELECTROPHORESIS AND CYCLODEXTRIN MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY

被引：45

作者：

OTSUKA, K

TERABE, S

机构：

[1] HIMEJI INST TECHNOL,FAC SCI,DEPT MAT SCI,KAMIGORI,HYOGO 67812,JAPAN

[2] STANFORD UNIV,DEPT CHEM,STANFORD,CA 94305

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 04期

关键词：

D O I：

10.1080/10826079308020945

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical resolution of RS-chlorpheniramine by cyclodextrin (CD) added capillary zone electrophoresis (CZE) and cyclodextrin modified micellar electrokinetic chromatography (CD-MEKC) was investigated. In CD added CZE, optical resolution was achieved with beta-CD - urea solutions (pH 2.5 - 3.0) with and without methanol. In this system, gamma-CD was not effective to achieve enantiomeric separation. In CD-MEKC, similar resolution as in the CD added CZE systems was obtained with sodium dodecyl sulfate (SDS) - beta-CD - urea solutions (pH 3.0).

引用

页码：945 / 953

页数：9

共 14 条

[1] SEPARATION OF OPTICAL ISOMERS BY CAPILLARY ZONE ELECTROPHORESIS BASED ON HOST GUEST COMPLEXATION WITH CYCLODEXTRINS [J].