Histopathological Pattern of Endometrium on Diagnostic D & C in Patients with Abnormal Uterine Bleeding

Aims and Objectives: To determine histopathological pattern of endometrium in patients with abnormal uterine bleeding. Study Type: Observational, Cross sectional. Place of Study: Obs and Gynae department, Madina teaching hospital, FSD. Duration of Study: One and a half year from Oct 2008 to Apr 2010. Patients and Methods: Patients presenting to Madina teaching hospital OPD with complaint of abnormal uterine bleeding were assessed via inclusion and exclusion criteria to be included in this study. A detailed history was followed by general physical, systemic, and gynecological examination. A pelvic ultrasound was performed followed by diagnostic D&C. Endometrial biopsy sent for histopathological examination in Pathology department of Madina teaching hospital, FSD. Data was collected over a period of one and a half year, and shifted to computer for analysis. Statistical package of social sciences (SPSS) version 15 was used for statistical analysis of data. Chi-square goodness of fit was used as test of statistical significance. Results: The most common pathological pattern identified was proliferative phase endometrium (46.4%). Secretary phase endometrium was second most common pathology (37.6%). Cystic (5.2%), adenomatous (3.8%), and atypical (3.6%) hyperplasia constituted 12.6% of bulk. In 1.4%, endometritis was identified as a cause of abnormal uterine bleeding followed by atrophic endometrium (1%). Polyp was identified in 0.6% of cases followed by endometrial carcinoma (0.4%). Conclusion: Histopathological pattern of endometrium in patients with abnormal uterine bleeding is quite variable regardless of age, parity and ethnicity. Although the incidence of endometrial hyperplasia is grossly variable, yet incidence of endometrial carcinoma is small in all sited studies.