GENETIC TOXICITY OF PROCARBAZINE IN BACTERIA AND YEAST

被引：17
作者：
BRONZETTI, G
ZEIGER, E
MALLING, HV
机构：
[1] NIEHS,ENVIRONM MUTAGENESIS LAB,RES TRIANGLE PK,NC 27709
[2] NIEHS,BIOCHEM GENET LAB,RES TRIANGLE PK,NC 27709
来源：
MUTATION RESEARCH | 1979年 / 68卷 / 01期
关键词：
D O I：
10.1016/0165-1218(79)90077-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Procarbazine [N-isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride] is used to treat Hodgkin's disease. This compound was tested in vitro without and with S10 fraction from mice liver (microsomal assay) using Saccharomyces cerevisiae strain D7, Salmonella typhimurium (strains TA98, TA100, TA1535) and in vivo in Swiss albino mice (host-mediated assay) using D7. Procarbazine, without S10 fraction, is highly toxic and induced mitotic crossover, gene conversion, and reverse mutation in D7. It had a toxic effect on all the Salmonella strains; but did not induce reverse mutations at the histidine loci. Procarbazine, with S10 fraction, was less toxic and did not induce genetic effects in yeast or Salmonella. In the host-mediated assay, no genetic effects were seen. © 1979.
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页码：51 / 58
页数：8
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