A NEW NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST

The structure of methyl 2-[(4-butyl-2-methyl-6-oxo-5-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1H-pyrimidinl-yl)methyl]-3-thiophenecarboxylate (LR-B/081), C30H30N6O3S, has been established by X-ray analysis. Partial disorder is observed in the terminal portion of the alkyl chain bonded to the pyrimidinone ring; the six atoms of the latter are coplanar to within 0.008(2) Angstrom. The crystal structure consists of infinite ribbons of molecules extended along the c axis of the orthorhombic cell (space group Pbca). Molecules within the ribbon are connected pairwise by an N-H ... N hydrogen bond between the tetrazole and the pyrimidinone rings, with an N ... N separation of 2.900 (3) A.