HUMAN N-METHYL-D-ASPARTATE RECEPTOR MODULATORY SUBUNIT HNR3 - CLONING AND SEQUENCING OF THE CDNA AND PRIMARY STRUCTURE OF THE PROTEIN

被引：18

作者：

ADAMS, SL ^{[1
]}

FOLDES, RL ^{[1
]}

KAMBOJ, RK ^{[1
]}

机构：

[1] ALLELIX BIOPHARMACEUT INC,MISSISSAUGA,ON L4V 1V7,CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1260卷 / 01期

关键词：

N-METHYL-D-ASPARTATE RECEPTOR; NMDA RECEPTOR; NR3; CDNA SEQUENCE; AMINO ACID SEQUENCE; (HUMAN);

D O I：

10.1016/0167-4781(94)00189-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several cDNA crones encoding the human N-methyl-D-aspartate receptor modulatory subunit hNR3, were isolated from a human fetal brain library. The hNR3 cDNA demonstrated a 91.3-91.5% nucleotide (nt) identity with the rat NR2B and mouse epsilon 2 cDNAs. The nt sequence of hNR3 would encode a 1484 amino acid (aa) protein that has a 98.4-98.5% identity with the mouse epsilon 2 and rat NR2B subunits.

引用

页码：105 / 108

页数：4

共 29 条

[21] MOLECULAR-CLONING, FUNCTIONAL EXPRESSION, AND PHARMACOLOGICAL CHARACTERIZATION OF AN N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT FROM HUMAN BRAIN [J].

PLANELLSCASES, R ;

SUN, W ;

FERRERMONTIEL, AV ;

MONTAL, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :5057-5061

[22] SUBUNIT-SPECIFIC BLOCK OF CLONED NMDA RECEPTORS BY ARGIOTOXIN636 [J].

RADITSCH, M ;

RUPPERSBERG, JP ;

KUNER, T ;

GUNTHER, W ;

SCHOEPFER, R ;

SEEBURG, PH ;

JAHN, W ;

WITZEMANN, V .

FEBS LETTERS, 1993, 324 (01) :63-66

[23] THE NMDA RECEPTOR COMPLEX [J].

SCATTON, B .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1993, 7 (08) :389-400

[24] PREFERENTIAL COASSEMBLY OF RECOMBINANT NMDA RECEPTORS COMPOSED OF 3 DIFFERENT SUBUNITS [J].

WAFFORD, KA ;

BAIN, CJ ;

LEBOURDELLES, B ;

WHITING, PJ ;

KEMP, JA .

NEUROREPORT, 1993, 4 (12) :1347-1349

[25] DEVELOPMENTAL-CHANGES IN DISTRIBUTION OF NMDA RECEPTOR CHANNEL SUBUNIT MESSENGER-RNAS [J].

WATANABE, M ;

INOUE, Y ;

SAKIMURA, K ;

MISHINA, M .

NEUROREPORT, 1992, 3 (12) :1138-1140

[26] DISTINCT DISTRIBUTIONS OF 5 N-METHYL-D-ASPARTATE RECEPTOR-CHANNEL SUBUNIT MESSENGER-RNAS IN THE FOREBRAIN [J].

WATANABE, M ;

INOUE, Y ;

SAKIMURA, K ;

MISHINA, M .

JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 338 (03) :377-390

[27] DEVELOPMENTAL SWITCH IN THE EXPRESSION OF NMDA RECEPTORS OCCURS INVIVO AND INVITRO [J].

WILLIAMS, K ;

RUSSELL, SL ;

SHEN, YM ;

MOLINOFF, PB .

NEURON, 1993, 10 (02) :267-278

[28]

WILLIAMS K, 1993, MOL PHARMACOL, V44, P851

[29] DIFFERENT SENSITIVITIES OF NMDA RECEPTOR-CHANNEL SUBTYPES TO NONCOMPETITIVE ANTAGONISTS [J].

YAMAKURA, T ;

MORI, H ;

MASAKI, H ;

SHIMOJI, K ;

MISHINA, M .

NEUROREPORT, 1993, 4 (06) :687-690

← 1 2 3 →