HUMAN N-METHYL-D-ASPARTATE RECEPTOR MODULATORY SUBUNIT HNR3 - CLONING AND SEQUENCING OF THE CDNA AND PRIMARY STRUCTURE OF THE PROTEIN

被引:18
作者
ADAMS, SL [1 ]
FOLDES, RL [1 ]
KAMBOJ, RK [1 ]
机构
[1] ALLELIX BIOPHARMACEUT INC,MISSISSAUGA,ON L4V 1V7,CANADA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1260卷 / 01期
关键词
N-METHYL-D-ASPARTATE RECEPTOR; NMDA RECEPTOR; NR3; CDNA SEQUENCE; AMINO ACID SEQUENCE; (HUMAN);
D O I
10.1016/0167-4781(94)00189-A
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several cDNA crones encoding the human N-methyl-D-aspartate receptor modulatory subunit hNR3, were isolated from a human fetal brain library. The hNR3 cDNA demonstrated a 91.3-91.5% nucleotide (nt) identity with the rat NR2B and mouse epsilon 2 cDNAs. The nt sequence of hNR3 would encode a 1484 amino acid (aa) protein that has a 98.4-98.5% identity with the mouse epsilon 2 and rat NR2B subunits.
引用
收藏
页码:105 / 108
页数:4
相关论文
共 29 条
[1]   RECOMBINANT IONOTROPIC GLUTAMATE RECEPTORS - FUNCTIONAL DISTINCTIONS IMPARTED BY DIFFERENT SUBUNITS [J].
BURNASHEV, N .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 1993, 3 (5-6) :318-331
[2]   SPLICE VARIANTS OF THE N-METHYL-D-ASPARTATE RECEPTOR NR1 IDENTIFY DOMAINS INVOLVED IN REGULATION BY POLYAMINES AND PROTEIN-KINASE-C [J].
DURAND, GM ;
BENNETT, MVL ;
ZUKIN, RS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6731-6735
[3]   HUMAN N-METHYL-D-ASPARTATE RECEPTOR MODULATORY SUBUNIT HNR2A - CLONING AND SEQUENCING OF THE CDNA AND PRIMARY STRUCTURE OF THE PROTEIN [J].
FOLDES, RL ;
ADAMS, SL ;
FANTASKE, RP ;
KAMBOJ, RK .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1994, 1223 (01) :155-159
[4]   CLONING AND SEQUENCE-ANALYSIS OF CDNAS ENCODING HUMAN HIPPOCAMPUS N-METHYL-D-ASPARTATE RECEPTOR SUBUNITS - EVIDENCE FOR ALTERNATIVE RNA SPLICING [J].
FOLDES, RL ;
RAMPERSAD, V ;
KAMBOJ, RK .
GENE, 1993, 131 (02) :293-298
[5]  
FOLDES RL, 1994, IN PRESS GENE
[6]  
FONG TM, 1992, J BIOL CHEM, V267, P25668
[7]   RECEPTOR SUBTYPES OR SPECIES HOMOLOGS - RELEVANCE TO DRUG DISCOVERY [J].
HALL, JM ;
CAULFIELD, MP ;
WATSON, SP ;
GUARD, S .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (10) :376-383
[8]   CLONED GLUTAMATE RECEPTORS [J].
HOLLMANN, M ;
HEINEMANN, S .
ANNUAL REVIEW OF NEUROSCIENCE, 1994, 17 :31-108
[9]   CLONING AND EXPRESSION OF THE EPSILON-4 SUBUNIT OF THE NMDA RECEPTOR CHANNEL [J].
IKEDA, K ;
NAGASAWA, M ;
MORI, H ;
ARAKI, K ;
SAKIMURA, K ;
WATANABE, M ;
INOUE, Y ;
MISHINA, M .
FEBS LETTERS, 1992, 313 (01) :34-38
[10]  
ISHII T, 1993, J BIOL CHEM, V268, P2836