TGF-BETA IS A POTENT INHIBITOR OF HEPATOCYTE GROWTH-FACTOR SECRETION BY HUMAN FIBROBLASTS

被引：65

作者：

GOHDA, E ^{[1
]}

MATSUNAGA, T ^{[1
]}

KATAOKA, H ^{[1
]}

YAMAMOTO, I ^{[1
]}

机构：

[1] OKAYAMA UNIV,FAC PHARMACEUT SCI,DEPT IMMUNOCHEM,OKAYAMA 700,JAPAN

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1992年 / 16卷 / 09期

关键词：

D O I：

10.1016/S0309-1651(06)80171-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor-β 1 (TGF-β 1) inhibited secretion of human hepatocyte growth factor (hHGF), which is also known as scatter factor or fibroblast-derived tumor cytotoxic factor, by MRC-5 cells. The effect was detectable at as little as 10 pg/ml and was more potent than that of dexamethasone. Complete inhibition was observed after 12 h in the presence of 5 ng/ml of TGF-β 1. Phorbol 12-myristate 13-acetate-induced secretion of hHGF from human skin fibroblasts was also suppressed by TGF-β 1. TGF-β 2 inhibited hHGF secretion by MRC-5 cells to the same extent as TGF-β 1, but other growth factors such as epidermal growth factor and acidic and basic fibroblast growth factors had only a slight or null inhibitory effect. © 1992 Academic Press Ltd.

引用

页码：917 / 926

页数：10

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