LOCKING IN STABLE STATES OF GENE-EXPRESSION - TRANSCRIPTIONAL CONTROL DURING DROSOPHILA DEVELOPMENT

被引：268
|
作者：
SIMON, J [1 ]
机构：
[1] UNIV MINNESOTA, DEPT GENET & CELL BIOL, ST PAUL, MN 55108 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 03期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/0955-0674(95)80093-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cell fate decisions can be maintained during long periods of developmental time by stable states of gene expression. The Polycomb group and trithorax group proteins of Drosophila are key transcriptional regulators that maintain stable expression states during development. Recent advances in knowledge about individual Polycomb group and trithorax group proteins, their mechanisms of action, and potential homologs in mice and humans are contributing to a greater understanding of their roles in gene expression and development.
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页码：376 / 385
页数：10
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