COMPATIBILITY STUDY OF METHOTREXATE WITH PVC BAGS AFTER REPACKAGING INTO 2 TYPES OF INFUSION ADMIXTURES

被引：8

作者：

BENAJI, B ^{[1
]}

DINE, T ^{[1
]}

GOUDALIEZ, F ^{[1
]}

LUYCKX, M ^{[1
]}

BRUNET, C ^{[1
]}

MALLEVAIS, ML ^{[1
]}

GRESSIER, B ^{[1
]}

CAZIN, M ^{[1
]}

CAZIN, JC ^{[1
]}

机构：

[1] LABS MACOPHARMA,F-59338 TOURCOING,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 105卷 / 01期

关键词：

COMPATIBILITY; PVC INFUSION BAG; METHOTREXATE; STORAGE;

D O I：

10.1016/0378-5173(94)90239-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stability and compatibility of methotrexate in admixtures for continuous intravenous infusion using PVC bags and administration set were studied. Methotrexate was reconstituted and diluted to 4.5 mg/ml for infusion in PVC containers, and to 0.225 and 24 mg/ml for storage in PVC bags containing 5% dextrose or 0.9% sodium chloride injections. Admixtures were stored at + 4-degrees-C and with protection from light for 30 days. Analyses were performed by HPLC. In every case, no significant drug loss was observed during storage or simulated infusions using PVC infusion bags and administration sets.

引用

页码：83 / 87

页数：5

共 21 条

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