ISOLATION OF THE OPIOID HEPTAPEPTIDE MET-ENKEPHALIN [ARG6,PHE7] FROM BOVINE ADRENAL-MEDULLARY GRANULES AND STRIATUM

被引：281
作者：
STERN, AS
LEWIS, RV
KIMURA, S
ROSSIER, J
GERBER, LD
BRINK, L
STEIN, S
UDENFRIEND, S
机构：
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 12期
关键词：
D O I：
10.1073/pnas.76.12.6680
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Bovine adrenal chromaffin granules have been shown to contain, in addition to Met-enkephalin and Leu-enkephalin, at least three small peptides with opiate receptor activity. One of these adrenal peptides has been purified to homogeneity and its sequence was shown to be Met-enkephalin-[Arg 6,Phe 7]. This heptapeptide was also found in beef striatal extracts in amounts comparable to those of Leu-enkephalin.
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页码：6680 / 6683
页数：4
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