GAS-CHROMATOGRAPHY MASS-SPECTROMETRY OF SOME STEROIDAL SPIROLACTONES

被引：1
作者：
BOREHAM, DR
VOSE, CW
BALASUBRAMANIAN, V
BROOKS, CJW
机构：
[1] GD SEARLE & CO LTD,LANE END RD,HIGH WYCOMBE HP12 4HL,ENGLAND
[2] UNIV GLASGOW,DEPT CHEM,GLASGOW G12 8QQ,SCOTLAND
来源：
ORGANIC MASS SPECTROMETRY | 1979年 / 14卷 / 08期
关键词：
D O I：
10.1002/oms.1210140810
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Gas chromatography mass spectrometry of a number of steroidal spirolactones and their TMS ethers is reported. Open tubular column gas chromatography provides useful structural information for these compounds as shown by shifts in retention index values. The electron impact fragmentation pathways have been established for a number of the compounds. The results of the study indicate that open tubular column gas chromatography mass spectrometry will be of value in studies of the metabolism of this class of steroids in animals and man. Copyright © 1979 John Wiley & Sons, Ltd.
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页码：442 / 447
页数：6
相关论文
共 20 条
[1]   APPLICATION OF ION-EXCHANGE AND LIPOPHILIC-GEL CHROMATOGRAPHY TO PURIFICATION AND GROUP FRACTIONATION OF STEROIDAL SPIROLACTONES, ISOLATED FROM BIOLOGICAL-FLUIDS [J].
BOREHAM, DR ;
VOSE, CW ;
PALMER, RF ;
BROOKS, CJW ;
BALASUBRAMANIAN, V .
JOURNAL OF CHROMATOGRAPHY, 1978, 153 (01) :63-75
[2]  
BOREHAM DR, 1978, BIOMED MASS SPECTROM, V5, P524, DOI 10.1002/bms.1200050904
[3]  
BOREHAM DR, 1977, 11TH FEBS M COP
[4]   USE OF TRIMETHYLSILYL ETHERS IN CHARACTERIZATION OF NATURAL STEROLS AND STEROID DIOLS BY GAS CHROMATOGRAPHY MASS SPECTROMETRY [J].
BROOKS, CJW ;
HENDERSO.W ;
STEEL, G .
BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 296 (02) :431-445
[5]   CORRELATION OF GAS-LIQUID CHROMATOGRAPHIC BEHAVIOUR AND STRUCTURE OF STEROIDS [J].
BROOKS, CJW ;
HANAINEH, L .
BIOCHEMICAL JOURNAL, 1963, 87 (01) :151-+
[6]  
BROOKS CJW, 1967, GAS CHROMATOGRAPHY H, P75
[7]  
BROOKS CJW, 1966, EXCERPTA MED, V132, P366
[8]   STEROIDAL ALDOSTERONE BLOCKERS .1. [J].
CELLA, JA ;
BROWN, EA ;
BURTNER, RR .
JOURNAL OF ORGANIC CHEMISTRY, 1959, 24 (06) :743-748
[9]   MASS SPECTROMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS .125. MASS SPECTROMETRY OF SOME STEROID TRIMETHYLSILYL ETHERS [J].
DIEKMAN, J ;
DJERASSI, C .
JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (04) :1005-&
[10]   MASS SPECTROMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS .78. STEROIDAL DELTA4-3,6-DIKETONES [J].
DJERASSI, C ;
KARLINER, J ;
APLIN, RT .
STEROIDS, 1965, 6 (01) :1-&
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