INTRACELLULAR CALCIUM AND PATHOPHYSIOLOGICAL CHANGES IN CEREBRAL-ISCHEMIA

被引：0

作者：

GREENBERG, JH ^{[1
]}

UEMATSU, D ^{[1
]}

ARAKI, N ^{[1
]}

REIVICH, M ^{[1
]}

机构：

[1] UNIV PENN,CEREBROVASC RES CTR,36TH & HAMILTON WALK,PHILADELPHIA,PA 19104

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1991年 / 41-1卷 / 3A期

关键词：

CALCIUM; INTRACELLULAR; CALCIUM CHANNELS; BLOCKERS; CAS-66085-59-4; CAS-77086-21-6; DIZOCILPINE; ISCHEMIA; CEREBRAL; NIMODIPINE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The role of calcium as a mediator in neuronal death during ischemia is now quite strong. Evidence supporting this link included studies in cell cultures, measurements of calcium accumulation in the mitochondria during ischemia as well as direct measurements of shifts in extracellular calcium using microelectrodes. Since high concentrations of intracellular free calcium have been hypothesized to lead to neuronal damage, direct in vivo measurements of this parameter in ischemia are important. The studies outlined demonstrate that changes in intracellular free calcium occur in focal ischemia and describe the time course of these changes. They indicate that cellular damage can be attenuated by the use of agents that block calcium channels (both voltage-sensitive and receptor-operated) and support the concept that these agents owe their beneficial effects to their ability to reduce the accumulation of intracellular calcium.

引用

页码：324 / 332

页数：9

共 30 条

[1] POSSIBLE ROLE OF CALCIUM ENTRY BLOCKERS IN BRAIN PROTECTION
BAETHMANN, A
JANSEN, M
[J]. EUROPEAN NEUROLOGY, 1986, 25 : 102 - 114
[2] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS
BENVENISTE, H
DREJER, J
SCHOUSBOE, A
DIEMER, NH
[J]. JOURNAL OF NEUROCHEMISTRY, 1984, 43 (05) : 1369 - 1374
[3] CHEUNG JY, 1986, NEW ENGL J MED, V314, P1670
[4] CALCIUM-MEDIATED NEUROTOXICITY - RELATIONSHIP TO SPECIFIC CHANNEL TYPES AND ROLE IN ISCHEMIC DAMAGE
CHOI, DW
[J]. TRENDS IN NEUROSCIENCES, 1988, 11 (10) : 465 - 469
[5] ANATOMICAL ORGANIZATION OF EXCITATORY AMINO-ACID RECEPTORS AND THEIR PATHWAYS
COTMAN, CW
MONAGHAN, DT
OTTERSEN, OP
STORMMATHISEN, J
[J]. TRENDS IN NEUROSCIENCES, 1987, 10 (07) : 273 - 280
[6] EXCITATORY AMINO-ACIDS IN THE BRAIN - FOCUS ON NMDA RECEPTORS
COTMAN, CW
IVERSEN, LL
[J]. TRENDS IN NEUROSCIENCES, 1987, 10 (07) : 263 - 265
[7] SODIUM-INDUCED EFFLUX OF CALCIUM FROM HEART-MITOCHONDRIA - POSSIBLE MECHANISM FOR REGULATION OF MITOCHONDRIAL CALCIUM
CROMPTON, M
CAPANO, M
CARAFOLI, E
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1976, 69 (02): : 453 - 462
[8] CALCIUM ACCUMULATION AND NEURONAL DAMAGE IN THE RAT HIPPOCAMPUS FOLLOWING CEREBRAL-ISCHEMIA
DESHPANDE, JK
SIESJO, BK
WIELOCH, T
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1987, 7 (01) : 89 - 95
[9] DORA E, 1985, ACTA PHYSIOL HUNG, V66, P199
[10] EFFECT OF ACUTE ARTERIAL-HYPOTENSION AND HYPERTENSION ON CEREBROCORTICAL NAD NADH REDOX STATE AND VASCULAR VOLUME
DORA, E
KOVACH, AGB
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1982, 2 (02) : 209 - 219

← 1 2 3 →