CALRETININ-IMMUNOREACTIVE NEURONS AND THEIR PROJECTIONS IN THE GUINEA-PIG COLON

被引:19
作者
MCCONALOGUE, K
LOW, AM
WILLIAMSON, S
BORNSTEIN, JC
FURNESS, JB
机构
[1] MCMASTER UNIV,DEPT BIOMED SCI,HAMILTON L8N 3Z5,ON,CANADA
[2] UNIV MELBOURNE,DEPT PHYSIOL,PARKVILLE,VIC 3052,AUSTRALIA
关键词
CALRETININ; ENTERIC NERVOUS SYSTEM; CALCIUM-BINDING PROTEIN; COLON; GUINEA-PIG;
D O I
10.1007/BF00306121
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The distribution of nerve cells and fibres with immunoreactivity for the calcium-binding protein, calretinin, was studied in the distal colon of the guinea-pig. The projections of the neurons were determined by examining the consequences of lesioning the myenteric plexus. Calretinin-immunoreactive neurons comprised 17% of myenteric nerve cells and 6% of submucous nerve cells. Numerous calretinin-immunoreactive nerve fibres were located in the longitudinal and circular muscle, and within the ganglia of the myenteric and submucous plexuses. Occasional fibres were found in the muscularis mucosae, but they were very rare in the lamina propria of the mucosa. Lesion studies revealed that myenteric neurons innervated the underlying circular muscle and provided both ascending and descending processes that gave rise to varicose branches in myenteric ganglia. Calretinin-immunoreactive fibres also projected to the tertiary component of the myenteric plexus, and are therefore likely to be motor neurons to the longitudinal muscle. Varicose fibres that supplied the submucous ganglia appear to arise from submucous nerve cells. Arterioles of the submucous plexus were sparsely innervated by calretinin-immunoreactive fibres. The submucous plexus was the principal source of immunoreactive nerve fibres in the muscularis mucosae. This work shows that calretinin-IR reveals different neuronal populations in the large intestine to those previously reported in the small intestine.
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页码:359 / 365
页数:7
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