ENANTIOMERIC SEPARATION OF AMPHETAMINE AND METHAMPHETAMINE BY CAPILLARY GAS-CHROMATOGRAPHY

被引：17

作者：

JIN, HL ^{[1
]}

BEESLEY, TE ^{[1
]}

机构：

[1] ADV SEPARAT TECHNOL INC,WHIPPANY,NJ 07981

来源：

CHROMATOGRAPHIA | 1994年 / 38卷 / 9-10期

关键词：

GAS CHROMATOGRAPHY; CHIRAL ENANTIOMERIC SEPARATION; AMPHETAMINE; METHAMPHETAMINE; CYCLODEXTRIN-DERIVATIZED PHASES;

D O I：

10.1007/BF02277160

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomeric separation of amphetamine and methamphetamine as achiral derivatives on 2,6-di-O-pentyl-3-O-trifluoroacetyl-beta-cyclodextrin, 2,6-di-O-pentyl-3-O-trifluoroacetyl-gamma-cyclodextrin and 2,6-di-O-pentyl-3-O-propionyl-gamma-cyclodextrin stationary phase in capillary gas chromatography is described. Trifluoroacetic anhydride and acetic anhydride were used as derivatizing reagents. Excellent precision was obtained for concentrations down to 0.1 % / e.e. On 2,6-di-O-pentyl-3-O-propionyl-gamma-cyclodextrin the elution order of R,S-amphetamine was reversed when the derivatizing reagent was changed but could not be reversed on any of the other phase types.

引用

页码：595 / 598

页数：4