REDUCTION OF NGF PROTEIN LEVEL IN RAT DORSAL HIPPOCAMPUS FOLLOWING ADMINISTRATION OF KAINIC ACID

被引：12

作者：

HASHIMOTO, Y

OMAE, F

FURUKAWA, S

机构：

[1] GIFU PHARMACEUT UNIV,DEPT MOLEC BIOL,GIFU 502,JAPAN

[2] MITSUI TOATSU CHEM CO LTD,LIFE SCI LABS,CHIBA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 02期

关键词：

NERVE GROWTH FACTOR; KAINIC ACID; NON-N-METHYL-D-ASPARTATE RECEPTOR; HIPPOCAMPUS; NORTHERN BLOT; ENZYME IMMUNOASSAY;

D O I：

10.1016/0304-3940(92)90103-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraperitoneal administration of kainic acid (KA) into adult rats caused a profound increase in nerve growth factor (NGF) mRNA and a significant reduction of NGF protein level in the hippocampus. Diazepam pretreatment suppressed both. The reduction of NGF level was apparent in the dorsal hippocampus at 2 h after KA administration, but a marked elevation of NGF protein was observed in the ventral hippocampus at 4 h. These results suggest that non-N-methyl-D-aspartate (NMDA) receptor agonists negatively influence NGF synthesis or stimulate NGF protein degradation in the dorsal hippocampus involving the CA1 sector.

引用

页码：203 / 205

页数：3

共 13 条

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