ADRENOCORTICAL ATROPHY OF HYPOPHYSECTOMIZED RATS CAN BE REDUCED BY CORTICOTROPIN-RELEASING HORMONE (CRH)

被引：45

作者：

BORNSTEIN, SR ^{[1
]}

EHRHART, M ^{[1
]}

SCHERBAUM, WA ^{[1
]}

PFEIFFER, EF ^{[1
]}

机构：

[1] UNIV BERGEN, DEPT PHYSIOL, N-5014 BERGEN, NORWAY

来源：

CELL AND TISSUE RESEARCH | 1990年 / 260卷 / 01期

关键词：

Adrenal cortex; Corticotropin-releasing hormone (CRH); Hypophysectomy; Rat (Sprague Dawley);

D O I：

10.1007/BF00297501

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effects of high dose injections of corticotropin-releasing hormone (CRH) on the adrenal cortex of hypophysectomized rats were studied at the light-and electron-microscopical levels. Adrenocortical atrophy induced by hypophysectomy could be reduced by daily i.p. injection of 10 μg (3 nmol) CRH given for 3 days starting at day 5 after the operation. The cortex broadened, mostly because of hypertrophy of the zona fasciculata. Blood vessels were enlarged. Although the adrenocortical cells of hypophysectomized rats showed features of a functionally suppressed state, such as tubular mitochondria, the cells of CRH-treated animals showed characteristics of stimulated cells. The inner membrane of the mitochondria formed the typical densely packed vesicles of adrenocortical cells that are active in steroidogenesis. Lipid droplets were found to be reduced, and the cells developed filopodia at their surface. These morphological observations indicate that CRH influences the adrenal cortex via extrapituitary mechanisms. © 1990 Springer-Verlag.

引用

页码：161 / 166

页数：6

共 27 条

[1] CORTICOTROPIN-RELEASING FACTOR RECEPTORS - DISTRIBUTION AND REGULATION IN BRAIN, PITUITARY, AND PERIPHERAL-TISSUES [J].