FURTHER BROMINATED BIS-INDOLE AND TRIS-INDOLE ALKALOIDS FROM THE DEEP-WATER NEW-CALEDONIAN MARINE SPONGE ORINA SP

被引：193

作者：

BIFULCO, G

BRUNO, I

RICCIO, R

LAVAYRE, J

BOURDY, G

机构：

[1] UNIV NAPLES FEDERICO II,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY

[2] RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,F-94403 VITRY,FRANCE

[3] ORSTOM,NOUMEA,NEW CALEDONIA

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 08期

关键词：

D O I：

10.1021/np50122a017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two tris-indole alkaloids, (+/-)-gelliusines A and B [1], have been isolated for the first time from a marine source, the New Caledonian sponge, Orina sp. (or Gellius sp.), along with five further indole constituents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-indolyl)-ethylamine, previously isolated from the tunicate Didemnum candidum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays.

引用

页码：1254 / 1260

页数：7

共 22 条

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Murray, LM
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AUSTRALIAN JOURNAL OF CHEMISTRY, 1995, 48 (12) : 2053 - 2058
[4] HAMACANTHIN-A AND HAMACANTHIN-B, NEW ANTIFUNGAL BIS INDOLE ALKALOIDS FROM THE DEEP-WATER MARINE SPONGE, HAMACANTHA SP
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JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (17): : 4772 - 4775
[6] TOPSENTINS, NEW TOXIC BIS-INDOLE ALKALOIDS FROM THE MARINE SPONGE TOPSENTIA-GENITRIX
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Chakrabarti, Debopam
Guzman, Esther A.
Harmody, Dedra
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MARINE DRUGS, 2017, 15 (01):
[8] Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge Myrmekioderma sp.
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ORGANIC LETTERS, 2021, 23 (09) : 3477 - 3480
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TETRAHEDRON LETTERS, 2000, 41 (33) : 6305 - 6308

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