FURTHER BROMINATED BIS-INDOLE AND TRIS-INDOLE ALKALOIDS FROM THE DEEP-WATER NEW-CALEDONIAN MARINE SPONGE ORINA SP

被引:196
作者
BIFULCO, G
BRUNO, I
RICCIO, R
LAVAYRE, J
BOURDY, G
机构
[1] UNIV NAPLES FEDERICO II,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY
[2] RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,F-94403 VITRY,FRANCE
[3] ORSTOM,NOUMEA,NEW CALEDONIA
来源
JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 08期
关键词
D O I
10.1021/np50122a017
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two tris-indole alkaloids, (+/-)-gelliusines A and B [1], have been isolated for the first time from a marine source, the New Caledonian sponge, Orina sp. (or Gellius sp.), along with five further indole constituents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-indolyl)-ethylamine, previously isolated from the tunicate Didemnum candidum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays.
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收藏
页码:1254 / 1260
页数:7
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