BINDING PROFILE OF SM-9018, A NOVEL ANTIPSYCHOTIC CANDIDATE

The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki=0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for α1 and D1 receptors (K4 = 17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for α2, opiate, glutamate, phencyclidine, benzodiazepine and GABAA receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT2 and 5-HT1A receptors. © 1990, The Japanese Pharmacological Society. All rights reserved.