GENETIC ESTIMATES FOR PLASMA-LIPIDS AND LIPOPROTEINS IN CYNOMOLGUS MONKEYS UNDER ASSORTATIVE MATING

被引：1

作者：

SPRAY, BJ ^{[1
]}

MORGAN, TM ^{[1
]}

CLARKSON, TB ^{[1
]}

机构：

[1] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT COMPARAT MED,WINSTON SALEM,NC 27157

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 08期

关键词：

PLASMA CHOLESTEROL; LOW DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN; HERITABILITY; REPEATABILITY; GENETIC CORRELATIONS;

D O I：

10.1111/j.1600-0684.1994.tb00134.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Data obtained from cynomolgus monkeys selected for total plasma cholesterol (TPC) response td dietary cholesterol and nonselected controls were used to estimate heritability of TPC and lipoprotein concentrations. A total of 345 observations were collected on 57 progeny from 18 sires. Heritability estimates obtained by a paternal half-sib analysis and by regression of offspring on mid-parent values were 0.45 +/- 0.24 and 0.69 +/- 0.18 for TPC, 0.63 +/- 0.30 and 0.64 +/- 0.17 for LDLC, and 0.80 +/- 0.36 and 0.59 +/- 0.14 for HDLC, respectively. These results suggest that TPC and lipoprotein concentrations are influenced by additive genetic effects in cynomolgus monkeys, establishing their importance as an animal model for studying the genetics of lipoproteins.

引用

页码：450 / 457

页数：8

共 7 条

[1] PLASMA-LIPIDS AND LIPOPROTEINS AND ESSENTIAL-HYPERTENSION
FLESCH, M
SACHINIDIS, A
KO, YD
KRAFT, K
VETTER, H
CLINICAL INVESTIGATOR, 1994, 72 (12): : 944 - 950
[2] ON THE EFFECT OF GARLIC ON PLASMA-LIPIDS AND LIPOPROTEINS IN MILD HYPERCHOLESTEROLEMIA
SIMONS, LA
BALASUBRAMANIAM, S
VONKONIGSMARK, M
PARFITT, A
SIMONS, J
PETERS, W
ATHEROSCLEROSIS, 1995, 113 (02) : 219 - 225
[3] Cross-trait assortative mating is widespread and inflates genetic correlation estimates
Border, Richard
Athanasiadis, Georgios
Buil, Alfonso
Schork, Andrew J.
Cai, Na
Young, Alexander I.
Werge, Thomas
Flint, Jonathan
Kendler, Kenneth S.
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Dahl, Andy W.
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[4] EFFECTS OF PROBUCOL ON PLASMA-LIPIDS, LIPOPROTEINS AND PARAMETERS OF HIGH-DENSITY-LIPOPROTEIN METABOLISM
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ALBERS, HW
LAMKIN, G
STEIN, EA
BARNHART, RL
CHI, EM
JACKSON, RL
HARMONY, JAK
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[5] DIETARY TRANS-FATTY-ACIDS - EFFECTS ON PLASMA-LIPIDS AND LIPOPROTEINS OF HEALTHY-MEN AND WOMEN
JUDD, JT
CLEVIDENCE, BA
MUESING, RA
WITTES, J
SUNKIN, ME
PODCZASY, JJ
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[6] Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys
Kempen, Herman J.
Gomaraschi, Monica
Bellibas, S. Eralp
Plassmann, Stephanie
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Collins, Heidi L.
Adelman, Steven J.
Calabresi, Laura
Wijngaard, Peter L. J.
JOURNAL OF LIPID RESEARCH, 2013, 54 (09) : 2341 - 2353
[7] WILL A HIGH-CARBOHYDRATE, LOW-FAT DIET LOWER PLASMA-LIPIDS AND LIPOPROTEINS WITHOUT PRODUCING HYPERTRIGLYCERIDEMIA
ULLMANN, D
CONNOR, WE
HATCHER, LF
CONNOR, SL
FLAVELL, DP
ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (04): : 1059 - 1067

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