COMPLEMENT-MEDIATED UNSPECIFIC BINDING OF IMMUNOGLOBULINS TO SOME ENDOCRINE-CELLS

被引：49
作者：
BUFFA, R
CRIVELLI, O
FIOCCA, R
FONTANA, P
SOLCIA, E
机构：
[1] UNIV PAVIA,INST PATHOL ANAT,I-27100 PAVIA,ITALY
[2] OSPED MAURIZIANO,DIV GASTRENTEROL,TORINO,ITALY
来源：
HISTOCHEMISTRY | 1979年 / 63卷 / 01期
关键词：
D O I：
10.1007/BF00508008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes. © 1979 Springer-Verlag.
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页码：15 / 21
页数：7
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