ANTI-DSDNA AND COMPLEMENT PROFILES AS PROGNOSTIC GUIDES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：272
作者：
SWAAK, AJG
AARDEN, LA
STATIUSVANEPS, LW
FELTKAMP, TEW
机构：
[1] UNIV AMSTERDAM,EXPTL & CLIN IMMUNOL LAB,AMSTERDAM 1004,NETHERLANDS
[2] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT AUTOIMMUNE DIS,AMSTERDAM,NETHERLANDS
来源：
ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 03期
关键词：
D O I：
10.1002/art.1780220304
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic lupus erythematosus. A longitudinal study showed a clear relation between the clinical state, the anti‐dsDNA titer (expressed in units), and the C1q and C3 levels: when anti‐dsDNA levels remained high, no exacerbations were observed. A sharp drop in anti‐dsDNA, usually preceded by a rise, was related to a serious exacerbation. Only during the exacerbation when both C1q and C3 were very low was renal involvement seen. Copyright © 1979 American College of Rheumatology
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页码：226 / 235
页数：10
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