THE SYNTHESIS OF 1-AMINOBENZYLPHOSPHONIC ACIDS FROM BENZYLIDENEDIPHENYLMETHYLAMINES, FOR USE AS STRUCTURAL UNITS IN ANTITHROMBOTIC TRIPEPTIDES

被引：33

作者：

GREEN, D

PATEL, G

ELGENDY, S

BABAN, JA

CLAESON, G

KAKKAR, VV

DEADMAN, J

机构：

来源：

TETRAHEDRON | 1994年 / 50卷 / 17期

关键词：

D O I：

10.1016/S0040-4020(01)90420-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acid hydrolyses of 0,0-dimethyl or 0,0-diethyl 1-(diphenylmethylamino) benzylphosphonate intermediates 2, formed from the addition at elevated temperature of dimethyl or diethyl phosphite to benzylidenediphenylmethylamines 1, generates 1-aminobenzylphosphonic acids 3 in good yield.

引用

页码：5099 / 5108

页数：10

共 32 条

[1]

AFARINKIA K, 1990, SYNLETT, P415

[2]

ATHERTON FR, 1980, Patent No. 1577232

[3]

BANNER DW, 1991, J BIOL CHEM, V266, P20085

[4] GEOMETRY OF BINDING OF THE BENZAMIDINE-BASED AND ARGININE-BASED INHIBITORS N-ALPHA-(2-NAPHTHYL-SULFONYL-GLYCYL)-DL-PARA-AMIDINOPHENYLALANYL-PIPERIDINE (NAPAP) AND (2R,4R)-4-METHYL-1-[N-ALPHA-(3-METHYL-1,2,3,4-TETRAHYDRO-8-QUINOLINESULPHONYL)-L-ARGINYL]-2-PIPERIDINE CARBOXYLIC-ACID (MQPA) TO HUMAN ALPHA-THROMBIN - X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE NAPAP-TRYPSIN COMPLEX AND MODELING OF NAPAP-THROMBIN AND MQPA-THROMBIN [J].