IDH-wildtype infiltrative low-grade glial tumor with nodule-like enhancement pattern

被引：1

作者：

Hanai, Sho ^{[1
]}

Ishikawa, Eiichi ^{[1
]}

Sakamoto, Noriaki ^{[2
]}

Miki, Shunichiro ^{[1
,3
]}

Ichimura, Koichi ^{[3
]}

Shibuya, Makoto ^{[4
]}

Nakao, Junzo ^{[1
]}

Matsuda, Masahide ^{[1
]}

Akutsu, Hiroyoshi ^{[1
]}

Takano, Shingo ^{[1
]}

Matsumura, Akira ^{[1
]}

机构：

[1] Univ Tsukuba, Dept Neurosurg, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tsukuba, Dept Pathol, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[3] Natl Canc Ctr, Div Brain Tumor Translat Res, Res Inst, Tokyo, Japan

[4] Tokyo Med Univ, Hachioji Med Ctr, Cent Lab, 1163 Tatemachi, Hachioji, Tokyo 1930998, Japan

来源：

INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT | 2018年 / 14卷

关键词：

D O I：

10.1016/j.inat.2018.07.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors describe a usual case of infiltrative low-grade glial neoplasm with a marked enhanced area which is difficult to diagnose. A 42-year-old man had the diffuse mass lesion partially with apparent enhancement in the right temporal lobe, the insular, and the basal ganglia regions. Final pathological diagnosis from the removed specimens was IDH-wildtype diffuse astrocytoma according to 2016 WHO classification, although it had unusual findings including gliomesenchymal reaction. The nodule-like enhancement was thought to be owing to the mesenchymal component. Several molecular analysis including pyrosequence analysis, Ion Torrent (TM) next-generation sequencing and multiplex ligation-dependent probe amplification analysis detected no genomic abnormality. IDH-wildtype diffuse astrocytoma is a heterogeneous category and has a minor subset with a silent genomic landscape like the present case.

引用

页码：111 / 114

页数：4

共 9 条

[1] Adult IDH wild-type lower-grade gliomas should be further stratified [J].

Aibaidula, Abudumijit ;

Chan, Aden Ka-Yin ;

Shi, Zhifeng ;

Li, Yanxi ;

Zhang, Ruiqi ;

Yang, Rui ;

Li, Kay Ka-Wai ;

Chung, Nellie Yuk-Fei ;

Yao, Yu ;

Zhou, Liangfu ;

Wu, Jinsong ;

Chen, Hong ;

Ng, Ho-Keung .

NEURO-ONCOLOGY, 2017, 19 (10) :1327-1337

[2]

Antonescu C. R., 2016, WHO IARC CLASSIFICAT, V1, P247

[3] Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma [J].

Ceccarelli, Michele ;

Barthel, Floris P. ;

Malta, Tathiane M. ;

Sabedot, Thais S. ;

Salama, Sofie R. ;

Murray, Bradley A. ;

Morozova, Olena ;

Newton, Yulia ;

Radenbaugh, Amie ;

Pagnotta, Stefano M. ;

Anjum, Samreen ;

Wang, Jiguang ;

Manyam, Ganiraju ;

Zoppoli, Pietro ;

Ling, Shiyun ;

Rao, Arjun A. ;

Grifford, Mia ;

Cherniack, Andrew D. ;

Zhang, Hailei ;

Poisson, Laila ;

Carlotti, Carlos Gilberto, Jr. ;

Tirapelli, Daniela Pretti da Cunha ;

Rao, Arvind ;

Mikkelsen, Tom ;

Lau, Ching C. ;

Yung, W. K. Alfred ;

Rabadan, Raul ;

Huse, Jason ;

Brat, Daniel J. ;

Lehman, Norman L. ;

Barnholtz-Sloan, Jill S. ;

Zheng, Siyuan ;

Hess, Kenneth ;

Rao, Ganesh ;

Meyerson, Matthew ;

Beroukhim, Rameen ;

Cooper, Lee ;

Akbani, Rehan ;

Wrensch, Margaret ;

Haussler, David ;

Aldape, Kenneth D. ;

Laird, Peter W. ;

Gutmann, David H. ;

Noushmehr, Houtan ;

Iavarone, Antonio ;

Verhaak, Roel G. W. .

CELL, 2016, 164 (03) :550-563

[4] Intracranial gliofibroma mimicking a meningioma: a case report and review of literature [J].

Deb, P ;

Sarkar, C ;

Garg, A ;

Singh, VP ;

Kale, SS ;

Sharma, MC .

CLINICAL NEUROLOGY AND NEUROSURGERY, 2006, 108 (02) :178-186

[5] PECULIAR NEOPLASIA OF COLLAGEN FORMING GLIA-LIKE CELLS [J].

FRIEDE, RL .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1978, 37 (03) :300-313

[6]

Giannini C., 2016, WHO CLASSIFICATION T, V1, P94

[7] Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas [J].

Okamoto, Y ;

Di Patre, PL ;

Burkhard, C ;

Horstmann, S ;

Jourde, B ;

Fahey, M ;

Schüler, D ;

Probst-Hensch, NM ;

Yasargil, MG ;

Yonekawa, Y ;

Lütolf, UM ;

Kleihues, P ;

Ohgaki, H .

ACTA NEUROPATHOLOGICA, 2004, 108 (01) :49-56

[8] Prognostic significance of imaging contrast enhancement for WHO grade II gliomas [J].

Pallud, Johan ;

Capelle, Laurent ;

Taillandier, Luc ;

Fontaine, Denys ;

Mandonnet, Emmanuel ;

Guillevin, Remy ;

Bauchet, Luc ;

Peruzzi, Philippe ;

Laigle-Donadey, Florence ;

Kujas, Michele ;

Guyotat, Jacques ;

Baron, Marie-Helene ;

Mokhtari, Karima ;

Duffau, Hugues .

NEURO-ONCOLOGY, 2009, 11 (02) :176-182

[9] Mutational landscape and clonal architecture in grade II and III gliomas [J].

Suzuki, Hiromichi ;

Aoki, Kosuke ;

Chiba, Kenichi ;

Sato, Yusuke ;

Shiozawa, Yusuke ;

Shiraishi, Yuichi ;

Shimamura, Teppei ;

Niida, Atsushi ;

Motomura, Kazuya ;

Ohka, Fumiharu ;

Yamamoto, Takashi ;

Tanahashi, Kuniaki ;

Ranjit, Melissa ;

Wakabayashi, Toshihiko ;

Yoshizato, Tetsuichi ;

Kataoka, Keisuke ;

Yoshida, Kenichi ;

Nagata, Yasunobu ;

Sato-Otsubo, Aiko ;

Tanaka, Hiroko ;

Sanada, Masashi ;

Kondo, Yutaka ;

Nakamura, Hideo ;

Mizoguchi, Masahiro ;

Abe, Tatsuya ;

Muragaki, Yoshihiro ;

Watanabe, Reiko ;

Ito, Ichiro ;

Miyano, Satoru ;

Natsume, Atsushi ;

Ogawa, Seishi .

NATURE GENETICS, 2015, 47 (05) :458-U52

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