T-CELL CYTOKINE RESPONSES IN HUMAN INFECTION WITH MYCOBACTERIUM-TUBERCULOSIS

被引：235

作者：

ZHANG, M

LIN, YG

IYER, DV

GONG, JH

ABRAMS, JS

BARNES, PF

机构：

[1] UNIV SO CALIF,SCH MED,DEPT MED,DIV INFECT DIS,LOS ANGELES,CA 90033

[2] DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA 94304

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 08期

关键词：

D O I：

10.1128/IAI.63.8.3231-3234.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4(+) cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.

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页码：3231 / 3234

页数：4

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