MK-801 INDUCED STEREOTYPIES IN RATS ARE DECREASED BY HALOPERIDOL AND INCREASED BY DIAZEPAM

被引：20

作者：

BEHRENS, S ^{[1
]}

GATTAZ, WF ^{[1
]}

机构：

[1] CENT INST MENTAL HLTH,NEUROBIOL FUNCT PSYCHOSES UNIT,POB 122120,W-6800 MANNHEIM 1,GERMANY

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1992年 / 90卷 / 03期

关键词：

MK-801; NMDA-ANTAGONISTS; HALOPERIDOL; DIAZEPAM;

D O I：

10.1007/BF01250962

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of haloperidol and diazepam were investigated on stereotypies (wall contacts and turn rounds) induced by the non-competitive NMDA antagonist MK-801 in rats. Haloperidol (0.03, 0.10, 0.25 and 0.40 mg/kg body weight) caused a dose-dependent antagonism whereas diazepam (3.0 and 5.0 mg/kg) caused a dose-dependent agonism of the stereotypies induced by 0.30 mg/kg MK-801 (all drugs given intraperitoneal). Conversely, diazepam (5.0 mg/kg) given alone reduced significantly the number of spontaneous wall contacts and turn rounds.The paradoxial stimulation of MK-801 induced stereotypies by diazepam could be explained by a shift between positive and negative corticostriatothalamic feedback loops envolving GABAergic neurons in favour of the former.

引用

页码：219 / 224

页数：6

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