A BOVINE CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE PLUS A THEILERIA-PARVA ANTIGEN RESEMBLES MOUSE H-2KD

被引：2
作者：
GODDEERIS, BM [1 ]
机构：
[1] INT LAB RES ANIM DIS, NAIROBI, KENYA
来源：
ANIMAL GENETICS | 1990年 / 21卷 / 03期
关键词：
cattle; cytotoxic T cell; MHC; Theileria;
D O I：
10.1111/j.1365-2052.1990.tb03243.x
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Summary Two BoT2+, BoT8+ cytotoxic T cell clones were generated from peripheral blood of a steer immunized with the intracellular protozoan parasite Theileria parva. Both cytotoxic T cell clones appeared to be restricted by the same major histocompatibility complex (MHC) molecule and were specific for the immunizing parasite clone. However, one of the two clones also recognized uninfected mouse cell lines carrying the H‐2d haplotype. Inhibition of cytotoxicity with monoclonal antibodies specific for polymorphic determinants on H‐2 molecules confirmed that this CTL clone recognized the H‐2Kd MHC molecule. These results extend to the bovine system observations in other species that foreign MHC mimics self MHC plus antigen. 1990 International Society for Animal Genetics
引用
收藏
页码：323 / 328
页数：6
相关论文
共 14 条
[1]   AN IMMUNOCHEMICAL ANALYSIS OF CLASS-I (BOLA) MOLECULES ON THE SURFACE OF BOVINE CELLS [J].
BENSAID, A ;
NAESSENS, J ;
KEMP, SJ ;
BLACK, SJ ;
SHAPIRO, SZ ;
TEALE, AJ .
IMMUNOGENETICS, 1988, 27 (02) :139-144
[2]  
BENSAID A, 1989, ANIM GENET, V20, P241
[3]   SIMULTANEOUS EXPRESSION OF H-2-RESTRICTED AND ALLOREACTIVE RECOGNITION BY A CLONED LINE OF INFLUENZA VIRUS-SPECIFIC CYTO-TOXIC LYMPHOCYTES-T [J].
BRACIALE, TJ ;
ANDREW, ME ;
BRACIALE, VL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 153 (05) :1371-1376
[4]   OF COWS AND MEN - A COMPARATIVE-STUDY OF HISTOCOMPATIBILITY ANTIGENS [J].
BRODSKY, FM ;
STONE, WH ;
PARHAM, P .
HUMAN IMMUNOLOGY, 1981, 3 (02) :143-152
[5]  
ENNIS PD, 1988, J IMMUNOL, V141, P642
[6]   BOVINE CYTOTOXIC T-CELL CLONES SPECIFIC FOR CELLS INFECTED WITH THE PROTOZOAN PARASITE THEILERIA-PARVA - PARASITE STRAIN SPECIFICITY AND CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION [J].
GODDEERIS, BM ;
MORRISON, WI ;
TEALE, AJ ;
BENSAID, A ;
BALDWIN, CL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (14) :5238-5242
[7]  
GOLDING H, 1985, J IMMUNOL, V134, P3557
[8]   PEPTIDE-DEPENDENT RECOGNITION OF H-2KB BY ALLOREACTIVE CYTO-TOXIC LYMPHOCYTES-T [J].
HEATH, WR ;
HURD, ME ;
CARBONE, FR ;
SHERMAN, LA .
NATURE, 1989, 341 (6244) :749-752
[9]   A T-CELL CLONE EXPRESSES 2 T-CELL RECEPTOR ALPHA-GENES BUT USES ONE ALPHA-BETA-HETERODIMER FOR ALLORECOGNITION AND SELF MHC-RESTRICTED ANTIGEN RECOGNITION [J].
MALISSEN, M ;
TRUCY, J ;
LETOURNEUR, F ;
REBAI, N ;
DUNN, DE ;
FITCH, FW ;
HOOD, L ;
MALISSEN, B .
CELL, 1988, 55 (01) :49-59
[10]  
MORRISON WI, 1990, CURR TOP MICROBIOL, V155, P79
12